KMID : 0360220110520040420
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Journal of the Korean Ophthalmological Society 2011 Volume.52 No. 4 p.420 ~ p.428
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An Association Study of Apolipoprotein E Gene Polymorphism and Cataracts
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Chi Mi-Jung
Im Jung-Soo Paik Hae-Jung
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Abstract
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Purpose: To evaluate the association of apolipoprotein E (APOE) polymorphism and cataracts in the Korean population.
Methods: The present research included participants from a population-based study in Incheon, Korea. A sample of 126 adults genotyped for polymorphisms of APOE underwent a medical interview, an eye examination which included visual acuity testing, slitlamp cataract evaluation and fundus examination. The APOE polymorphism was determined using a polymerase chain reaction method.
Results: Eighty-eight participants (69.8%) were diagnosed with cataracts or had undergone cataract surgery in 1 or both eyes, and 38 participants (30.2%) demonstrated no signs of cataract. The frequencies of the APOE genotypes and alleles were not significantly different from the cataract and the control group. APOE ¥å2 carriers were less likely to have cataracts than non-¥å2 carriers with an odds ratio of 0.367 which was almost statistically significant with the multiple logistic regression analysis (p = 0.052).
Conclusions: There was no significant correlation of APOE genotype and cataracts. However, a slight negative association of APOE ¥å2 and cataracts were found in the Korean population.
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KEYWORD
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Apolipoprotein E, Cataract, Gene polymorphism
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